author = {Onwukwe, Chikezie. and Chikezie, Nkiru. and Okorie, Kalu. and Ohwovoriole, Augustine.}, title = {{Phenotypes of high-density lipoprotein cholesterol and their relationship with glycemic status in type 2 diabetic patients}}, journal ={Journal of Diabetes and Endocrine Practice}, volume ={4}, number ={2}, pages = {59-63}, doi = {10.4103/jdep.jdep_4_21}, year = {2021}, abstract ={ Background: There are varying reports on the association of high-density lipoprotein cholesterol (HDL-C) phenotypes and glycemia in type 2 diabetes mellitus (T2D) patients. Such information is lacking in Nigerian data. Aim: The aim of this study was to determine the relationship between HDL-C phenotypes and glycemic control in T2D patients. Materials and Methods: Clinical and laboratory data were collected from consenting T2D patients. Information was managed and analyzed with appropriate software. Results: Four hundred T2D patients consisting of 235 and 165 persons with and without poor glycemic control, respectively, were recruited for this study. There was a significant negative correlation between glycosylated hemoglobin (HbA1c) and the HDL2-C phenotype (rs = −0.12, P = 0.01). The correlation between HbA1c and the HDL3-C phenotype was not statistically significant (rs = −0.06, P = 0.21). Conclusion: The HDL2 phenotype has a stronger correlation with glycemic status than the HDL3 phenotype in T2D patients. }, URL ={https://www.jdeponline.com/article.asp?issn=2772-7653;year=2021;volume=4;issue=2;spage=59;epage=63;aulast=Onwukwe;t=6}, eprint ={https://www.jdeponline.com/article.asp?issn=2772-7653;year=2021;volume=4;issue=2;spage=59;epage=63;aulast=Onwukwe;t=6} }