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ORIGINAL ARTICLE
Year : 2020  |  Volume : 3  |  Issue : 2  |  Page : 70-74

Evaluation of Ischemia-Modified Albumin and Fibrinogen in Relation with High-Sensitive C-reactive Protein in Diabetic Foot Ulcers


1 A J Institute of Medical Sciences and Research Centre, Kuntikana, Mangalore, Karnataka, India
2 Department of Biochemistry, A J Institute of Medical Sciences and Research Centre, Kuntikana, Mangalore, Karnataka, India
3 Department of Surgery, Wayanad Institute of Medical Sciences, Meppadi, Kerala, India
4 Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, USA

Correspondence Address:
Dr. Madan Gopal Ramarajan
Department of Biochemistry, A J Institute of Medical Sciences and Research Centre, Kuntikana, Mangalore - 575 007, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jdep.jdep_15_19

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Context: Diabetic foot ulcer (DFU) is one of the most dreaded complication of diabetes which often affects the morbidity and mortality of a diabetic. Biomarkers are required for follow-up of these patients to prevent further complications to the affected limb. Aim: The aim of this study is to evaluate ischemia-modified albumin (IMA), fibrinogen in relation with high sensitive-C-reactive protein (hs-CRP) in patients with DFUs. Methods: a hospital-based cross-sectional study was carried out among 30 patients with DFU admitted in the surgery department of tertiary care teaching hospital. The duration of the study was 2 months. Serum IMA, hs-CRP, and plasma fibrinogen levels were measured. Results: The present study has demonstrated that IMA levels (P < 0.05) and fibrinogen levels (P < 0.05) are statistically significantly elevated in patients with DFU and had significant correlation with albumin and hs-CRP (P < 0.05). Conclusions: The use of IMA, hs-CRP, and fibrinogen may be incorporated during the follow-up of type 2 diabetes mellitus patients and may probably prevent the development of DFU and also possibly prevent lower limb amputation. Further studies with a larger number of patients with DFU are necessary to reach a definitive judgment.


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