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Year : 2021  |  Volume : 4  |  Issue : 2  |  Page : 59-63

Phenotypes of high-density lipoprotein cholesterol and their relationship with glycemic status in type 2 diabetic patients

1 Division of Endocrinology and Diabetes, Al Isawiya General Hospital, Ministry of Health, Directorate of Gurayat, Kingdom of Saudi Arabia
2 Public Health Specialist, Department of Community Medicine, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra, Nigeria
3 Consultant Cardiologist, Department of Medicine, Cedarcrest Hospitals, Gudu, Abuja, Nigeria
4 Professor of Medicine and Consultant Endocrinologist, College of Medicine, University of Lagos, Lagos, Nigeria

Correspondence Address:
Dr. Chikezie Hart Onwukwe
Division of Endocrinology and Diabetes, Al Isawiya General Hospital, Ministry of Health, Directorate of Gurayat
Kingdom of Saudi Arabia
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jdep.jdep_4_21

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Background: There are varying reports on the association of high-density lipoprotein cholesterol (HDL-C) phenotypes and glycemia in type 2 diabetes mellitus (T2D) patients. Such information is lacking in Nigerian data. Aim: The aim of this study was to determine the relationship between HDL-C phenotypes and glycemic control in T2D patients. Materials and Methods: Clinical and laboratory data were collected from consenting T2D patients. Information was managed and analyzed with appropriate software. Results: Four hundred T2D patients consisting of 235 and 165 persons with and without poor glycemic control, respectively, were recruited for this study. There was a significant negative correlation between glycosylated hemoglobin (HbA1c) and the HDL2-C phenotype (rs = −0.12, P = 0.01). The correlation between HbA1c and the HDL3-C phenotype was not statistically significant (rs = −0.06, P = 0.21). Conclusion: The HDL2 phenotype has a stronger correlation with glycemic status than the HDL3 phenotype in T2D patients.

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